Answer:
Correct answer is Iran and Iraq .
Step-by-step explanation:
As Safavid Empire existed between 16th and 18th Century, when the Ottomans were also an important factor in the region. That is why answers that include Turkey and Israel are not correct, as they were part of Ottoman Empire.
Logically, first, third and fourth options are therefore wrong.
Second option is correct as this countries were the center of the Empire.