The correct answer to this open question is the following.
Although you forgot to include the options of the question, we can answer the following,
The statement that best explains how the development of humanism during the Renaissance affected artists differently than during the Middle Ages is the following: "Renaissance artists focused more on creating human, lifelike figures than Medieval artists did."
Besides that, during the Italian Renaissance, the idea that humans were special creatures with special characteristics that denoted its human nature, allowed a change of the old and dark conception of religious teachings that dominated over the Middle Ages. Furthermore, human artistic expression flourished like never before. Great examples of this are the beautiful artistic expressions of artists like Michel Angelo, Leonardo Da Vinci, and Raphael.