Question

What stimulates histamine
release?​

Answer 1

The Fc region of immunoglobulin E becomes bound to mast cells and basophils and when immunoglobulins paratopes bind to an antigen it causes the cells to release histamine and other inflammatory mediators.

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Answer 2

The Fc region of immunoglobulin E becomes bound to mast cells and basophils and when immunoglobulin's paratopes bind to an antigen, it causes the cells to release histamine and other inflammatory mediators.