Answer:
If we multiply both the sides by 2, the inequality signs remains the same.
If we divide both sides by -2, the sign changes. 
Explanation:
The given inequality is 
 -8<2 
If we multiply both the sides by 2, we get 
-8 * 2 < 2*2 
-16 < 4
The inequality signs remains the same. 
On the other hand if we divide both sides by -2, we get - 
-8/-2 < 2/-2
4 > -1
Here the sign changes.