Question

Negative selection in B and T lymphocytes occurs when ____.

Answer 1

Negative selection occurs when double positive T cells bind to bone-marrow derived APC (macrophages and dendritic cells) expressing Class I or Class II MHC plus self peptides with a high enough affinity to receive an apoptosis signal.

Step-by-step explanation:

• The regulation of central B cell tolerance has been extensively studied in both mice and humans and mainly involves the negative selection of autoreactive immature B cells in the bone marrow through the recognition of self-antigens by BCRs and potentially TLRs (3–8).
• The regulation of central B cell tolerance has been extensively studied in both mice and humans and mainly involves the negative selection of autoreactive immature B cells in the bone marrow through the recognition of self-antigens by BCRs and potentially TLRs (3–8).