Final answer:
Non-regulatory enzymes such as extracellular enzymes do not require coenzymes for their activity. Caseinase is an example of an extracellular protease, which operates independently of coenzymes.
Step-by-step explanation:
The activity of Enzymes Without Coenzymes
The enzymes that do not require coenzymes for their activity are intracellular enzymes. These enzymes are produced by the cell and function inside the same cell. Examples of intracellular enzymes include the enzymes involved in glycolysis and the TCA cycle. Enzymes that do not require coenzymes for their activity are generally known as non-regulatory enzymes. These enzymes, unlike regulatory enzymes, carry out their catalytic functions without the need for additional non-protein molecules. For example, extracellular enzymes such as trypsin and pancreatic lipase are produced by a cell and act outside of it, operating independently of coenzymes. In contrast, enzymes like phosphofructokinase and glutamate dehydrogenase, which are often intracellular enzymes, may require coenzymes derived from dietary vitamins for their activity. In the case of caseinase, it is a type of enzyme that falls under the category of extracellular proteases because it acts outside the cell and does not necessitate a coenzyme for its proteolytic activity on casein.