The frequency of wipe sampling by the pharmacist-in-charge depends on the specific requirements of the pharmacy and the regulations in the jurisdiction where it is located. However, as a general guideline, it is recommended that wipe sampling be performed at least quarterly. Therefore, option 4: Quarterly is the most appropriate answer to this multiple-choice question. This frequency allows for regular monitoring of the cleanliness of the pharmacy and identification of any potential issues that need to be addressed. However, if the pharmacy is compounding hazardous drugs or has a high-risk environment, more frequent wipe sampling may be necessary. It is important to note that the pharmacist-in-charge should also follow any specific guidelines or regulations set forth by their state board of pharmacy or other regulatory agencies.