Question

Tay Sachs is a congenital disorder in which molecules called gangliosides are not properly digested and instead accumulate in cells, causing toxicity. Misfunction in which organelle can lead to Tay Sachs? (Choice A) A Lysosome (Choice B) B Golgi Apparatus (Choice C) C Rough Endoplasmic Reticulum (Choice D) D Nucleus

Answer 1

OPTION A.

Tay Sachs disease is caused by a malfunction in the lysosomes, which fail to break down gangliosides, leading to cellular accumulation and neuron destruction.

Step-by-step explanation:

The misfunction in the organelle responsible for Tay Sachs disease is the lysosome. Tay Sachs is a genetic disorder that results in the accumulation of gangliosides within cells because the lysosomal enzymes needed to break down these molecules are missing or malfunctioning. This accumulation leads to the destruction of neurons and severe neurological damage. As the Golgi apparatus is responsible for the packaging and transport of lysosomal enzymes, any disruption in the function of the Golgi apparatus can lead to inherited diseases like the congenital disorders of glycosylation. However, in the case of Tay Sachs, the primary issue lies within the lysosomes themselves, not the Golgi apparatus.

Answer 2

the correct answer is (Choice A) A Lysosome.Tay Sachs disease is caused by the dysfunction of lysosomes, which fail to properly digest gangliosides due to a deficiency in the enzyme hexosaminidase A.

Step-by-step explanation:

The misfunction in the organelle responsible for Tay Sachs disease, which is a genetic disorder resulting in the accumulation of gangliosides causing toxicity and neuron destruction, is the lysosome.

Lysosomes are responsible for digesting various types of biomolecules, including gangliosides, through enzymes. In Tay Sachs, the enzyme necessary to digest gangliosides is missing or nonfunctional, leading to their accumulation. The lack of proper lysosomal function is the cause of various inherited diseases, including Tay Sachs, where the enzyme hexosaminidase A is not properly synthesized or functioning.

Therefore, the correct answer is (Choice A) A Lysosome.