Lissencephaly is a condition causing a lack of gyri and sulci in the brain, leading to a smooth surface. This negatively affects the cortex, disrupting functionality and leading to cognitive impairment, developmental delays, seizures, and more.
Lissencephaly is a rare, gene-linked brain malformation characterized by the absence or underdevelopment of the convolutions in the brain, leading to a smooth surface. This lack of gyri and sulci, the ridges and grooves respectively that typically characterize a brain, affects the cerebral cortex - the outer layer of brain tissue.
The cortex is responsible for many complex brain functions, including memory, attention, perceptual awareness, thought, language, and consciousness. When lissencephaly occurs and disrupts the normal formation of these structures, it can impact these functions. Patients with this condition can suffer from cognitive impairment, developmental delays, muscle spasms, seizures, and abnormal motor functions.
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