Final answer:
The Hittites controlled much of the territory between Mesopotamia and the Nile during the second millennium BCE. They established an empire in north-central Anatolia that reached its peak in the mid-14th century BC.
Step-by-step explanation:
The kingdom that controlled much of the territory between Mesopotamia and the Nile during the second millennium BCE was the Hittites. The Hittites were an ancient Anatolian people who established an empire at Hattusa in north-central Anatolia around the 18th century BC. This empire reached its height during the mid-14th century BC under Suppiluliuma I, when it encompassed an area that included most of Asia Minor as well as parts of the northern Levant and Upper Mesopotamia.
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