Question

Which can produce a negative nitrite test in the presence of significant bacteriuria?

Answer 1

Gram-positive uropathogens do not produce nitrite reductase and therefore when infection is due to these bacteria, the dipstick will be negative for nitrite.

Answer 2

A urine pH below 6.0, the amount of bacteriuria, the short time between collection and testing, dilute urine, and the presence of blood, urobilinogen, vitamin C, or medications can all cause a false-negative nitrite result.

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