Answer:
C - Italian Wars
Step-by-step explanation:
In the 15th and 16th centuries, the European nations sought alternate routes to the major trade centers of that time, India and China. This was due to the disruption of the usual trade routes caused by the Italian Wars.
A series of conflicts involving various European powers such as France, Spain, and the Roman Empire, the Italian wars affected the lands which were the major trade hubs with the Eastern nations. In need of various resources, and access to goods from India and China, various famous explorers such as Vasco da Gama, Christopher Columbus, etc. set on voyages to discover new naval routes to the East. This was named the 'Age of Exploration', and it establishes direct trade networks between Europe and South East Asia by sea.