Answer:
Step-by-step explanation:
The European nation that conquered Colombia, Venezuela, and Ecuador by the mid-1500s was Spain. Spain's colonization efforts in the Americas were led by explorers such as Christopher Columbus and later followed by conquistadors like Francisco Pizarro and Diego de Almagro. Through a combination of military conquest, political maneuvering, and alliances with indigenous groups, Spain established its control over these territories, incorporating them into its colonial empire in the region.