Answer: vvvv
Step-by-step explanation:
Sickling, which occurs in individuals with sickle cell disease, is more likely to happen when red blood cells (RBCs) are low in oxygen. This is because the mutated form of hemoglobin in sickle cell disease, called hemoglobin S, can polymerize or clump together when it is deoxygenated, causing RBCs to become rigid and distorted. When RBCs are exposed to low oxygen conditions, such as during physical exertion or at high altitudes, the likelihood of sickling increases, leading to various complications associated with sickle cell disease.