Final answer:
Particularists respond to skeptics by emphasizing the importance of direct experience and personal acquaintance with something as a source of knowledge.
Step-by-step explanation:
Particularists respond to skeptics by challenging the assumption that they beg the question that they have knowledge. Rather than assuming knowledge, particularists argue that knowledge is acquired through direct experience and acquaintance with something, rather than being mediated by inference.
They advocate for a standpoint epistemology, which examines the relationship between an individual's social status and their epistemic position. By emphasizing the importance of direct contact and personal experience, particularists argue against the skeptical view that all knowledge is impossible.