Final answer:
The question asks if mutations in alpha-tubulin genes decrease alpha-secretase activity. Without specific evidence linking alpha-tubulin to alpha-secretase, an accurate response cannot be provided, as the given references do not establish such a connection.
Step-by-step explanation:
The question pertains to whether mutations in the gene encoding alpha-tubulin affect alpha-secretase activity. Genetic mutations can have various effects depending on the protein's role and interaction with other cellular components. For example dominant negative mutations can result in a gene product that negatively affects the normal functioning of the wild-type gene product. Besides, mutations in the promoter region of a gene can decrease transcription rates by altering the binding site for transcription factors. Yet, the relationship between alpha-tubulin and alpha-secretase activity is not directly mentioned in the provided information. Therefore, without evidence to support a connection between mutations in alpha-tubulin genes and alpha-secretase activity, the answer would be based on speculation.