Final answer:
Langerhans cells, critical in defending against microbes, are dendritic cells located in the stratum spinosum layer of the skin, functioning as macrophages to contribute to immune responses.
Step-by-step explanation:
Langerhans cells, which play a role in defence against microbes, are a type of specialized dendritic cells found specifically in the stratum spinosum layer of the epidermis. These cells function similarly to macrophages, engulfing and digesting pathogens as part of the body's immune defence. They are adept at capturing antigens from invading microbes and then presenting these antigens to T cells in the lymph nodes, thereby initiating an adaptive immune response.