Final answer:
True. A mutation that does not change the amino acid sequence of a polypeptide cannot have occurred in an exon.
Step-by-step explanation:
A mutation that does not produce a change to the amino acid sequence of a polypeptide cannot have occurred in an exon. This statement is true. Exons are the coding regions of genes, and they contain the instructions for producing proteins.
Mutations that occur in exons can alter the amino acid sequence, which can affect the structure and function of the protein.
Therefore, if a mutation does not lead to a change in the amino acid sequence, it cannot be located in an exon.