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2 votes
Bone resulting from the use of demineralized human graft materials probably forms by:

a. Autogenesis
b. Guided tissue regeneration
c. Endochondral formation
d. Intramembranous formation

1 Answer

2 votes

Final answer:

Bone formed using demineralized human graft materials likely results from intramembranous ossification, a process where osteoprogenitor cells on the graft differentiate into osteoblasts and create new bone directly from connective tissue.

Step-by-step explanation:

Bone resulting from the use of demineralized human graft materials most likely forms through intramembranous ossification. This is because intramembranous ossification involves the process of bone development directly from sheets of mesenchymal connective tissue. In contrast, endochondral ossification, which involves bone development from hyaline cartilage, is not the typical pathway for demineralized grafts as they do not possess cartilaginous structures.

In the context of bone grafting, demineralized bone matrix (DBM) is used as a scaffold for osteoprogenitor cells, which differentiate into osteoblasts. These osteoblasts then secrete the extracellular matrix and begin the mineralization process, eventually forming new bone. This reiterates the principle that all bone formation is a replacement process, where a scaffold, in this case, the DBM, is replaced by new bone tissue through the activity of osteoblasts.

Thus, the correct answer to the question is d. Intramembranous formation.

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User Realharry
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