Final answer:
Heavy prolonged use of alcohol is the most likely to result in seizures during withdrawal, and should be overseen by medical professionals. Methadone can be used to manage heroin withdrawal symptoms and reduce relapse risk.
Step-by-step explanation:
Heavy prolonged use of alcohol is most likely to result in seizures during withdrawal. Among the substances listed, alcohol withdrawal can be particularly dangerous, possibly leading to a life-threatening condition known as delirium tremens, which includes seizures as one of the symptoms. On the other hand, heroin withdrawal, while extremely uncomfortable, does not typically cause seizures. It is important for individuals withdrawing from heavy and prolonged alcohol use to do so under medical supervision because of these severe withdrawal risks.
Moreover, a person with a heroin addiction might be prescribed the psychoactive drug methadone to help manage withdrawal symptoms and to reduce the potential for relapse. Methadone is a long-acting opioid that can alleviate the craving and withdrawal effects associated with heroin use without producing the intense euphoria, thus supporting recovery and rehabilitation.