Question

C1-inhibitor deficiency (rare, autosomal dominant disorder) results in...? (leads to continued activation of C1 & complement cascade)

Answer 1

C1-inhibitor deficiency (a rare autosomal dominant disorder) leads to continued activation of C1 and the complement cascade, resulting in swelling and fluid buildup in tissues.

Step-by-step explanation:

C1-inhibitor deficiency, an autosomal dominant disorder, leads to continued activation of C1 and the complement cascade.

Normally, C1 esterase inhibitors help suppress the activation of the complement system, but in individuals with C1-inhibitor deficiency, these proteins are deficient or nonfunctional.

As a result, the system becomes overstimulated, leading to the production of inflammatory anaphylatoxins, which can cause swelling and fluid buildup in tissues.