Final answer:
The statement is true; cortisol can indeed inhibit the release of CRH and ACTH as part of a negative feedback loop involving the hypothalamus and anterior pituitary.
Step-by-step explanation:
The statement that cortisol can inhibit the production of CRH (corticotropin releasing hormone) and ACTH (adrenocorticotropic hormone) by negatively feeding back on the hypothalamus and anterior pituitary is true.
This is part of a negative feedback loop where elevated levels of cortisol, which is a glucocorticoid hormone, signal the hypothalamus and the anterior pituitary gland to stop or reduce the secretion of CRH and ACTH, respectively.
Such regulation is crucial for maintaining hormonal balance and responding appropriately to stress.
For example, during long-term stress, cortisol promotes the catabolism of various stored nutrients to ensure adequate energy supply.