Question

Which kind of metabolic poison would most directly interfere with glycolysis :

a) ATP synthase inhibitor
b) Hexokinase activator
c) Phosphofructokinase inhibitor
d) Pyruvate kinase stimulator

Answer 1

The metabolic poison that would most directly interfere with glycolysis is Phosphofructokinase inhibitor (option c).

Step-by-step explanation:

The metabolic poison that would most directly interfere with glycolysis is Phosphofructokinase inhibitor (option c).

Phosphofructokinase is the main enzyme controlled in glycolysis. High levels of ATP, citrate, or a lower pH decrease the enzyme's activity. An increase in citrate concentration can occur because of a blockage in the citric acid cycle.

Therefore, a phosphofructokinase inhibitor would directly interfere with glycolysis by reducing the activity of this enzyme.