Question

Which basal factor stabilizes the elongating RNA pol II complex and decreases pausing?

A) TFIIB.
B) TFIIH.
C) TFIIA.
D) TFIIE.
E) TFIIF.

Answer 1

TFIIF is the basal transcription factor that stabilizes the elongating RNA polymerase II complex and reduces pausing during eukaryotic transcription.

Step-by-step explanation:

In eukaryotic transcription, various basal transcription factors are required to form the preinitiation complex and recruit RNA polymerase II to the promoter of a gene. These factors begin with "TFII" and are followed by another letter which indicates the specific factor.

Among these factors, TFIIF is known to stabilize the elongating RNA polymerase II complex and helps in decreasing pausing, allowing the transcription machinery to synthesize mRNA efficiently.