Question

What is more likely to be rearranged first, the light Kappa or Light lambda gene?

a) Light Kappa gene
b) Light lambda gene
c) Both are equally likely
d) Neither, they rearrange simultaneously

Answer 1

The light lambda gene is more likely to be rearranged first than the light Kappa gene.

Step-by-step explanation:

The light lambda gene is more likely to be rearranged first than the light Kappa gene. This is because the light lambda gene undergoes a process called gene rearrangement through VJ recombination, where V (variable) and J (joining) gene segments are randomly excised and spliced together to form a unique variable region of the light chain. On the other hand, the light Kappa gene undergoes gene rearrangement through VJ recombination and DNA rearrangement through V(D)J recombination, which involves additional steps. Therefore, the light lambda gene is more likely to be rearranged first.