Final answer:
The folded-three-dimensional conformation of a polypeptide does represent its tertiary structure, which is essential for the protein's biological function.
Step-by-step explanation:
The statement that the folded-three dimensional conformation of a polypeptide represents its tertiary structure is true. This conformation is crucial for the biological activity of proteins, including enzymes and immunoglobulins. The primary structure, which is the sequence of amino acids, folds into secondary structures such as the α-helix and β-pleated sheets. These secondary structures then fold and interact further to form the more complex three-dimensional tertiary structure, which is stabilized by various types of bonds and interactions. This tertiary level of organization is essential for the protein's biochemical functions.