Final answer:
Britain and France most interfered with Italy’s desire to establish an empire in Africa, influencing key decisions and controlling areas that Italy aspired to colonize.
Step-by-step explanation:
The two nations that most interfered with Italy’s desire to establish an empire in Africa were Britain and France. During the Scramble for Africa, Italy targeted East Africa, specifically Eritrea and Ethiopia. However, Britain and France had significant interests in Africa as well. For instance, Britain had Cecil Rhodes in South Africa's diamond trade, and during the Congress of Berlin, Britain influenced the decision to grant France control over Tunisia to secure French support for British claims elsewhere, diverting French attention from continental Europe which pleased Germany. This action denied Italy the chance to control Tunisia, reflecting Britain and France's interference in Italian colonial ambitions.
Other related events in the colonial context include the Fashoda Incident, where France and Britain vied for control of Sudan to connect their colonies via rail, further exemplifying the tensions and competition between European powers in Africa during this period.