Question

How to distinguish melanoma vs paget's disease of breast with stains?

A) Melanoma stains positive for S100, while Paget's disease stains positive for cytokeratin
B) Melanoma stains positive for cytokeratin, while Paget's disease stains positive for S100
C) Both melanoma and Paget's disease stain positive for S100
D) Neither melanoma nor Paget's disease stain positive for S100 or cytokeratin

Answer 1

Melanoma stains positive for S100 while Paget's disease stains positive for cytokeratin.

Step-by-step explanation:

The correct answer is A) Melanoma stains positive for S100, while Paget's disease stains positive for cytokeratin.

Staining is a technique used in pathology to identify specific molecules or structures in tissue samples. Melanoma is a type of skin cancer that arises from melanocytes, the cells responsible for producing the pigment melanin. Melanoma stains positive for S100, a protein marker that is commonly used to identify melanocytic tumors.

Paget's disease of the breast is a type of breast cancer that affects the cells of the nipple and areola. It typically presents with eczema-like changes on the nipple and is often associated with an underlying breast carcinoma. Paget's disease of the breast stains positive for cytokeratin, a protein marker that is used to identify epithelial cells, such as those found in breast tissue.