Question

You are caring for a patient with CKD (chronic kidney disease) who is on several medications. You will expect:

a)The urine creatinine clearance to be low and thus will worry about accumulation of drug metabolites in the patient's body.
b) Increased renal excretion leading to faster drug elimination
c) Normal kidney function with no impact on medication clearance
d) Elevated urine creatinine clearance due to the medications

Answer 1

In patients with CKD on multiple medications, one would expect a low urine creatinine clearance, indicating impaired kidney function and a higher risk of drug metabolites accumulating in the body.

Step-by-step explanation:

When caring for a patient with CKD (chronic kidney disease) who is on several medications, one would expect the urine creatinine clearance to be low, indicating a reduction in glomerular filtration rate (GFR). This reduced clearance means the kidneys are not functioning at full capacity to remove waste products, including metabolites of drugs, from the body. Consequently, there is a risk of accumulation of drug metabolites in the patient's body, which can lead to toxicity if medication doses are not properly adjusted.

Chronic kidney disease impacts the kidney's excretory function, often leading to an elevated serum creatinine level and a decrease in GFR. In clinical practice, GFR is commonly estimated by measuring creatinine clearance, and a decline in renal function necessitates careful assessment to avoid potential drug toxicity due to diminished renal excretion.

Therefore, the correct expectation would be: a) The urine creatinine clearance to be low and thus will worry about accumulation of drug metabolites in the patient's body.