Question

Acts on local muscle to increase temperature. Signal to liver to make acute phase reactants. Mannose binding lectin and C-reactive protein.

a) Interleukin-1
b) Interleukin-6
c) Interferon-gamma
d) Tumor necrosis factor-alpha (TNF-α)

Answer 1

The substance that acts on local muscle to increase temperature and signals the liver to make acute phase reactants is Interleukin-6 (IL-6).

Step-by-step explanation:

The substance described in the question acts on local muscle to increase temperature, signals the liver to make acute phase reactants such as mannose-binding lectin and C-reactive protein. The correct answer is Interleukin-6 (option b). Interleukin-6 (IL-6) is a cytokine that plays a central role in the inflammatory response, including the increase of body temperature during fever and the production of acute phase proteins by the liver. IL-6 acts on muscles and induces their heat production, while also signaling the liver to release proteins that support the body’s immune response to injury or infection.