Question

Variation in which two genes is known to greatly increase the risk of venous thrombosis in women using oral contraceptives?

A C-reactive protein and factor V
B Factor VIII and factor IX
C Factor IX and factor X
D C-reactive protein and prothrombin
E Factor V and prothrombin

Answer 1

Factor V and prothrombin are the two genes that greatly increase the risk of venous thrombosis in women using oral contraceptives.

Step-by-step explanation:

The variation in two genes known to greatly increase the risk of venous thrombosis in women using oral contraceptives are Factor V and prothrombin.

The presence of specific mutations in these genes increases the risk of blood clots forming in the veins, particularly when combined with the use of oral contraceptives.

For example, Factor V Leiden is a common mutation in the Factor V gene that is associated with an increased risk of blood clots. Prothrombin G20210A is a mutation in the prothrombin gene that is also associated with an increased risk of blood clots.

Answer 2

The variation in genes Factor V and prothrombin is known to greatly increase the risk of venous thrombosis in women using oral contraceptives.

The corret option is E.

Step-by-step explanation:

Factor V and prothrombin gene mutations, specifically Factor V Leiden mutation and prothrombin gene mutation (commonly known as G20210A mutation), significantly increase the risk of venous thrombosis in women who use oral contraceptives. These mutations lead to a hypercoagulable state, predisposing individuals to blood clot formation.

So, the correct option is E) Factor V and prothrombin.