Question

Following the first pregnancy with an Rh+ fetus, the immune system of an an Rh- woman produces anti-D antibodies. During her next pregnancy the baby is at risk of developing Hemolytic Disease of the Newborn (HDN), but only if which of the following is true?

Answer 1

Hemolytic Disease of the Newborn (HDN) can occur during the second or subsequent pregnancies of an Rh- woman if she has formed anti-D antibodies during a prior pregnancy. Anti-D antibodies can cross the placenta and destroy fetal red blood cells, causing anemia. Rho(D) immune globulin is given to prevent HDN.

Step-by-step explanation:

Hemolytic Disease of the Newborn (HDN) can occur during the second or subsequent pregnancies of an Rh- woman if she has formed anti-D antibodies during a prior pregnancy. These antibodies are produced in response to the mixing of maternal and fetal blood during childbirth.

Unlike antibodies against ABO antigens, anti-D antibodies can cross the placenta and destroy fetal red blood cells, causing anemia. To prevent HDN, an Rh- woman is given a medication called Rho(D) immune globulin.