Final answer:
Valproic acid should be administered with meals to reduce gastrointestinal upset and enhance tolerability, although it can also be taken with a full glass of water, it's not required.
Step-by-step explanation:
A client has a prescription for valproic acid orally once daily. The nurse should plan to administer the medication with meals to enhance tolerability and reduce gastrointestinal upset. It is not necessary to take it at bedtime, though some individuals may do so to coincide with their usual meal times or to reduce potential drowsiness that may occur. Taking the medication with a full glass of water can also help in the ease of swallowing the drug and in reducing gastrointestinal side effects, but it's not the primary directive. Administering the medication on an empty stomach is not recommended as it can cause stomach irritation.