Question

Which of the following changes will produce a right-shift in the oxygen-hemoglobin equilibrium curve (i.e, increase P₅₀)?

A. local alkalosis (increase in pH)
B. local ocidosis (decrease in pH)
C. increase in the allosteric organic modulator 2.3-BPG(bisphosphoglycerate)
D. decrease in temperature
E. decrease in the allosteric organic modulator 2.3-BPG (bisphosphoglycerate)
F. increase in temperature

Answer 1

Local ocidosis (decrease in pH), a decrease in the allosteric organic modulator 2,3-BPG (bisphosphoglycerate), or a decrease in temperature would produce a right-shift in the oxygen-hemoglobin equilibrium curve (increase P₅₀).

Step-by-step explanation:

The right shift in the oxygen-hemoglobin equilibrium curve, increasing P₅₀, can be caused by local ocidosis (decrease in pH), a decrease in the allosteric organic modulator 2,3-BPG (bisphosphoglycerate), or a decrease in temperature. Local alkalosis (increase in pH), an increase in the allosteric organic modulator 2,3-BPG (bisphosphoglycerate), or an increase in temperature would cause a left shift in the curve, decreasing P₅₀.

A right-shift in the oxygen-hemoglobin equilibrium curve is caused by factors that decrease the affinity of hemoglobin for oxygen. These include local acidosis (decrease in pH), an increase in temperature, and a rise in the concentration of 2,3-BPG. Therefore, options B, C, and F will lead to an increase in P50.