Final answer:
The INK4 CDKIs proteins inhibit D-CDK4/6 at S phase.
Step-by-step explanation:
Cyclins regulate the cell cycle by tightly binding to Cdks and forming Cdk/cyclin complexes. These complexes must be phosphorylated to become fully active and advance the cell to the next phase. There are also molecules called Cdk inhibitors that prevent the full activation of Cdks and block the cell cycle progression until certain events are completed. Therefore, the statement that the INK4 CDKIs proteins inhibit D-CDK4/6 at S phase is true.