Question

Place the following events in the proper order

1) Activation of one or more cellular signaling proteins
2) dissociation of G alpha from the G protein complex
3) Production of a second messenger, like cAMP
4) replacement of GDP by GTP on the G alpha after interaction with an activated GPCR
5) conformational change in the G alpha subunit causing a decreased affinity for the G beta and gamma subunit
6) G alpha subunit with its attached GTP activates an effector like adenylyl cyclase

Answer 1

The proper order of events in cell signaling using G-protein-linked receptors are activation of cellular signaling proteins, dissociation of G alpha from the G protein complex, replacement of GDP by GTP on the G alpha, conformational change in G alpha subunit, activation of an effector, and production of a second messenger.

Step-by-step explanation:

The proper order of the given events in the cell signaling process using G-protein-linked receptors is as follows:

Activation of one or more cellular signaling proteins.

Dissociation of G alpha from the G protein complex.

Replacement of GDP by GTP on the G alpha after interaction with an activated GPCR.

Conformational change in the G alpha subunit causing a decreased affinity for the G beta and gamma subunit.

G alpha subunit with its attached GTP activates an effector like adenylyl cyclase.

Production of a second messenger, like cAMP.