Question

What does an apoenzyme require to become a holoenzyme?

Answer 1

Apoenzyme needs binding with non proteinaceous small molecules called cofactors to become active. When apoenzyme binds with cofactor, the complex is known as holoenzyme. Holoenzyme is catalytically active to initiate the chemical reaction. The substrate binds with the holoenzyme, not with the apoenzyme.

Step-by-step explanation:

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