"Pangs of dispriz'd love" is an expression used to portray heartache. More precisely, in the play Hamlet falls in love with Ophelia who is told by her father to reject any advances by Hamlet. This hurts and confuses Hamlet and causes him much distress in the play. However when news of his father's death comes about, and he can no longer spend energy sulking over his unrequited love, Ophelia feels betrayed which ultimately leads to her death.