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The occurrence of withdrawal symptoms signals that the body has adjusted to the presence of the drug. indicates that substance abuse has developed. is seen when use of any psychoactive substance is terminated. is necessary for a diagnosis of substance dependence.

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The occurrence of withdrawal symptom is signals that the body has adjusted to the presence of the drug. Occurrence of withdrawal in critically ill sedated children. The frequency of withdrawal symptoms was 35% of the sedated children. A total dose of midazolam of less than 60 mg/kg was strongly significantly associated with occurrence of withdrawal.
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User Jeanetta
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