Answer: Irrelevant.
Explanation:
Changes in the genetic make up of the organism can be defined as the changes in the nucleotide sequence that is associated with genes.
Normally, many genetic mutation takes place in the body of the organism on a daily basis which is not at all observed because it has no effect on the phenotype or genotype of the organism.
So, most of the changes in the genetic make up of the organism is irreverent.