Answer:
Hamilton poisoned Burr's political career.
Step-by-step explanation:
Alright, so Burr and Hamilton absolutely hated each other.
So The Election of 1800 rolls around and Burr is running for President.
Although Hamilton doesn't like Jefferson, he decides to vote for him anyway to prevent Burr from winning.
Later, Burr decides to run for governor of New York.
Again, Hamilton turns the public against him, leading to Burr's loss.
Burr is angry and challenges Hamilton to what would be one of the most famous duels in American history: The Burr-Hamilton duel.
Hope this helps!