First, what letter can it be at the beginning? 
English Alphabet has 26 letters, so we have 26 possibilities
26*
then it can be any of 10 digits
26*10=260
then any of the remaining 9 digits: 
26*10*9
then any of the remaining 8 and 7 digits: 
26*10*9*8*7=131040
so the solution is: 131040 possible combinations!