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Why do some t cells remain in the body ,even after successfully getting rid of an intruder?

2 Answers

5 votes

Final answer:

Memory T cells and B cells survive after an infection to provide a rapid and enhanced response if the pathogen is encountered again, often stopping reinfection before it becomes symptomatic.

Step-by-step explanation:

After an infection has been cleared, most T cells and B cells die off, but a subset of these cells known as memory T cells and memory B cells remain in the body. These memory cells retain a 'recollection' of the pathogen, holding onto specific receptors highly affine to the previously encountered antigen. Therefore, if the same pathogen invades the body again, these memory cells quickly proliferate, mounting a rapid immune response without the need for antigen presentation by APCs or activation by helper T cells. This accelerated response, led predominantly by memory T cells differentiating into cytotoxic T lymphocytes (CTLs) and memory B cells converting into plasma cells, is more efficient and can often neutralize an infection before it becomes symptomatic.

Furthermore, memory T cells have the role of assisting other parts of the immune system. Helper T cells, for example, secrete cytokines that control the activity of other immune cells and are essential for coordinating an immune response. They too can form memory cells that aide in a faster and stronger response upon reexposure to the same antigen.

answered
User Elena  Unanyan
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8.4k points
5 votes
This happens because some of them become memory T cells. Memory T cells have become "experienced" by having encountered antigen during a primary infection. Next time when those cells encounter the invader, the immune response is much faster and stronger than the first time.
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User Koosa
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7.3k points
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