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What substance was responsible for a major ozone depletion in the 1900s?

What substance was responsible for a major ozone depletion in the 1900s?
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What substance was responsible for a major ozone depletion in the 1900s?

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User Issaka
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Chlorofluorocarbons was the main substance that depleted the ozone in the 1900s.
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User DGarvanski
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