Question

You are part of a team of doctors doing a Phase 2 study of teixobactin on humans. Assuming protocol had not changed since the mice study, how are you administering the drug?

You are part of a team of doctors doing a Phase 2 study of teixobactin on humans. Assuming protocol had not changed since the mice study, how are you administering the drug?
orally
through a nasal spray
by injection
rectally

Answer 1

The drug teixobactin is a relatively new antibiotic that acts as a cell wall synthesis inhibitor (similar to penicillin but different mode of action). Teixobactin is active against many gram positive bacteria. Since the protocol had not been changed since the mice study, the drug should be administered by injection either intravenously (if toxicity of the drug is negligible or tolerable) or intramuscularly/subcutaneously (to have the drug in depot and release it slowly in the bloodstream). With this, the drug will have 100% bioavailability in the human body and studies can account with the antibacterial properties of teixobactin in vivo.