The correct answers are "The Great Famine of 1315" and the Plague.
The Black Plague, which lasted from 1347 to 1351, was one of the most devasting events regarding human health. The estimated death toll due to this event ranges from 75 to 200 million people.
On the other hand, the great famine of 1315 lasted 2 years and signaled one of the most important food crisis of history. Effects of this event were high crime rates, disease, and cannibalism.