Answer:
The arrival of Europeans to the Americas after their discovery by Christopher Columbus in 1492 implied a series of radical changes in the lives of the natives.
The natives, until that time, had remained isolated against European civilizations: their only contact was with other native groups, with whom they shared social, cultural and even physical characteristics. The arrival of the Europeans implied a break in this regard, as it was the first contact with a group that was absolutely different from the American Indian groups.
Once the colonization of the continent by the Europeans had been arranged, a period of suffering began for the Native Americans. This period was marked by the wars of conquest, in which the Europeans prevailed for having more advanced weapons; diseases, since the arrival of Europeans caused large outbreaks of smallpox within native populations; and finally slavery, since the defeated natives were taken as slaves within the encomienda system, forced to work the lands that were once theirs.