The correct answer is D) inspire appreciation for beauty associated with strangeness.
What Edgar Allan Poe said of the Unity of effect should do to the reader of a poem was "inspire appreciation for beauty associated with strangeness."
What Edgar Allan Poe is referring to with this statement is the emotional factor or the emotion the poem should transmit to the reader. The poem has to "awaken" senses when the reader enjoys a poem. The author should evoke feelings and create emotions that the reader could understand and be part of.