Answer:
Transcription.
Step-by-step explanation:
Protein synthesis involves two steps, transcription and translation. During transcription, DNA makes a complementary RNA molecular and information for protein formation present in DNA gets transferred to the mRNA molecule.
The mRNA is then, transported to the ribosomes present in cytosol, where translation takes place. During translation, polypeptide chain or protein is synthesized by using information present in mRNA.
Thus, the first step in protein making from DNA instructions is 'transcription.'