Answer and Explanation:
Most enzymes are proteins in nature hence they are sensitive to changes in the pH. Enzymes may be denatured by extreme levels of hydrogen ions. Any change in pH, even a small one, alters the degree of ionization of an enzyme’s acidic and basic side groups and the substrate components as well. Ionizable side groups located in the active site must have a certain charge for the enzyme to bind its substrate. Neutralization of even one of these charges alters an enzyme’s catalytic activity. Excessive acidity or alkalinity renders them inactive.